DETAILED NOTES ON ALLERGY AND CLINICAL IMMUNOLOGY

Yet another DNA-centered approach is to combine allergen with bacterial DNA sequences that incorporate CpG motifs to selectively concentrate on Toll-like receptor nine (TLR9) expressed on human B cells and dendritic cells. The key ragweed pollen allergen Amb a 1 covalently linked to a B-form CpG-containing oligodeoxynucleotide (ODN)131 was profitab